Python - IOError: [Errno 13] Permission denied

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IOError: [Errno 13] Permission denied 

Solution:

It looks like you're trying to replace the extension with the following code:

if (myFile[-4:] == ".asm"):
    newFile = myFile[:4]+".hack"

However, you appear to have the array indexes mixed up. Try the following:

if (myFile[-4:] == ".asm"):
    newFile = myFile[:-4]+".hack"

Note the use of -4 instead of just 4 in the second line of code. This explains why your program is trying to create /Use.hack, which is the first four characters of your file name (/Use), with .hack appended to it.